CSS Grid frameworks are one of my newest favorite things. I have been using the 960 Grid for my portfolio redesign, and it has made my life 1000000 times easier.
Here is a collection of a wide array of grid frameworks for all my web people out there:
http://www.tripwiremagazine.com/tools/design/45-css-grid-systems-layout-generators-and-tutorials-that-every-designer-should-know.html
Chatter